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Utilization of COMPBIO was recently described in a PNAS publication from the Gordon Lab at Washington University entitled 'Mechanisms by which sialylated milk oligosaccharides impact bone biology in a gnotobiotic mouse model of infant undernutrition.' (May 28th, 2019 https://doi.org/10.1073/pnas.1821770116 )    

Based on differential expression of 164 genes, three key cellular and molecular pathway findings (eosinophil status, tuft cell increases, and succinate pathway activity)  were predicted by COMPBIO’s Biological Knowledge Generation Engine, and subsequently validated in the laboratory.   These novel findings may provide a mechanistic linkage between bone formation, the gut microbiota and cellular signaling within the intestinal mucosa.

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PercayAI

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